Chiral Phosphine-Free Pd-Mediated Asymmetric Allylation of Prochiral Enolate with a Chiral Phase-Transfer Catalyst
Masayoshi Nakoji, Takatoshi Kanayama, Tomotaka Okino and Yoshiji Takemoto*
*Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan,
Email: takemoto
pharm.kyoto-u.ac.jp
M. Nakoji, T. Kanayama, T. Okino, Y. Takemoto, Org. Lett., 2001, 3, 3329-3331.
DOI: 10.1021/ol016567h
Abstract
A chiral phase-transfer catalyst enables an asymmetric Pd-catalyzed allylation of a tert-butyl glycinate-benzophenone Schiff base with various allylic acetates to give the allylated products in good yields and high enantioselectivity without any chiral ligands.
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Key Words
O'Donnell Amino Acid Synthesis, Tsuji-Trost reaction, α-Amino Esters
ID: J54-Y2001
