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Nickel-Promoted Alkylative or Arylative Carboxylation of Alkynes

Masanori Takimoto, Kazuya Shimizu and Miwako Mori*

*Graduate School of Pharmaceutical Scieneces, Hokkaido University, Sapporo 060-0812, Japan

M. Takimoto, K. Shimizu, M. Mori, Org. Lett., 2001, 3, 3345-3347.

DOI: 10.1021/ol016585z (free Supporting Information)


Abstract

The reaction of alkynes with Ni(cod)2 and CO2 gave a nickelacycle, which was reacted with various organozinc reagents under very mild conditions to provide β,β-disubstituted, α,β-unsaturated carboxylic acids in a highly regio- and stereoselective manner.

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Key Words

carboxylation, substitution


ID: J54-Y2001