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New Ammonia Equivalents for the Pd-Catalyzed Amination of Aryl Halides

Xiaohua Huang and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email:

X. Huang, S. L. Buchwald, Org. Lett., 2001, 3, 3417-3419.

DOI: 10.1021/ol0166808

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LiN(SiMe3)2, Ph3SiNH2, and LiNH2 can be be used as ammonia equivalents for the Pd-catalyzed coupling of aryl halides to provide simple anilines, including ortho-substituted ones, as well as di- and triarylamines.

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Key Words

Buchwald-Hartwig Coupling, Anilines

ID: J54-Y2001