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5-Endo Trig Oxidative Radical Cyclizations of Ugi-3CR Products toward 1,4-Imidazolidinones

Kevin Schofield, Christopher Foley and Christopher Hulme*

*Department of Chemistry and Biochemistry, College of Science, The University of Arizona, Tucson, Arizona 85721, United States, Email:

K. Schofield, C. Foley, C. Hulme, Org. Lett., 2021, 23, 107-112.

DOI: 10.1021/acs.orglett.0c03785

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A 5-endo trig oxidative radical cyclization of benzylamine-derived Ugi three-component reaction products rapidly affords imidazolidinones. This oxidative radical cyclization generates highly decorated privileged heterocycles.

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proposed mechanism

Key Words

1,4-Imidazolidinones, PIDA

ID: J54-Y2021