5-Endo Trig Oxidative Radical Cyclizations of Ugi-3CR Products toward 1,4-Imidazolidinones
Kevin Schofield, Christopher Foley and Christopher Hulme*
*Department of Chemistry and Biochemistry, College of Science, The University of Arizona, Tucson, Arizona 85721, United States,
Email: hulme
pharmacy.arizona.edu
K. Schofield, C. Foley, C. Hulme, Org. Lett., 2021, 23, 107-112.
DOI: 10.1021/acs.orglett.0c03785
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Abstract
A 5-endo trig oxidative radical cyclization of benzylamine-derived Ugi three-component reaction products rapidly affords imidazolidinones. This oxidative radical cyclization generates highly decorated privileged heterocycles.
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proposed mechanism
Key Words
ID: J54-Y2021
