Synthesis of Nitrogen-Containing Heterocycles through Catalytic Dehydrative Cyclization Reactions
Freddy O. Rodriguez del Rey and Paul E. Floreancig*
*Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States, Email: floreanpitt.edu
F. O. R. del Rey, P. E. Floreancig, Org. Lett., 2021, 23, 150-154.
see article for more reactions
Re2O7 in hexafluoroisopropyl alcohol provides access to cationic intermediates from alcohols through the intermediacy of perrhenate esters. This system can be applied to the formation of a number of weakly basic heterocyclic systems through dehydration reactions and intramolecular nucleophilic addition.
see article for more examples
Rate Differences between Isomeric Substrates