Nickel-Catalyzed [4 + 2] Annulation of Nitriles and Benzylamines by C-H/N-H Activation
Rina Sikari, Gargi Chakraborty, Amit Kumar Guin and Nanda D. Paul*
*Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, Botanic Garden, Howrah 711103, India, Email: ndpaulgmail.com
R. Sikari, G. Chakraborty, A. K. Guin, N. D. Paul, J. Org. Chem., 2021, 86, 279-290.
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An atom-economic nickel-catalyzed [4 + 2] annulation of benzylamines and nitriles provides a wide variety of multisubstituted quinazolines via C-H/N-H bond activation. The Ni catalyst is directed by an in situ formed amidine to activate the C-H bond in ortho.
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