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Nickel-Catalyzed [4 + 2] Annulation of Nitriles and Benzylamines by C-H/N-H Activation

Rina Sikari, Gargi Chakraborty, Amit Kumar Guin and Nanda D. Paul*

*Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, Botanic Garden, Howrah 711103, India, Email:

R. Sikari, G. Chakraborty, A. K. Guin, N. D. Paul, J. Org. Chem., 2021, 86, 279-290.

DOI: 10.1021/acs.joc.0c02069

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An atom-economic nickel-catalyzed [4 + 2] annulation of benzylamines and nitriles provides a wide variety of multisubstituted quinazolines via C-H/N-H bond activation. The Ni catalyst is directed by an in situ formed amidine to activate the C-H bond in ortho.

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Key Words


ID: J42-Y2021