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Potassium tert-Butoxide Promoted Synthesis of 4,5-Diaryl-2H-1,2,3-triazoles from Tosylhydrazones and Nitriles

Shanguang Qiu, Yuxue Chen, Xinming Song, Li Liu, Xi Liu, Luyong Wu*

*Key Laboratory of Tropical Medicinal Resource Chemistry, Hainan Normal University, No. 99, Longkun South Road, Haikou 571158, P. R. of China, Email:

S. Qiu, Y. Chen, X. Song, L. Liu, X. L. Liu, L. Wu, Synlett, 2021, 32, 86-90.

DOI: 10.1055/s-0040-1707321

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t-BuOK promoted an intermolecular cycloaddition of tosylhydrazones with nitriles to provide 4,5-diaryl-2H-1,2,3-triazoles in very good yields. Homocoupling of the tosylhydrazones was significantly inhibited by using xylene as solvent.

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Key Words

2H-1,2,3-triazoles, tosylhydrazones, cycloaddition, potassium butoxide

ID: J72-Y2021