Manganese-Catalyzed N-F Bond Activation for Hydroamination and Carboamination of Alkenes

Yun-Xing Ji, Jinxia Li, Chun-Min Li, Shuanglin Qu* and Bo Zhang*

*College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082; China Pharmaceutical University, Nanjing 210009, China, Email: squhnu.edu.cn, zb3981444cpu.edu.cn

Y.-X. Ji, J. Li, C.-M. Li, S. Qu, B. Zhang, Org. Lett., 2021, 23, 207-212.

DOI: 10.1021/acs.orglett.0c03916

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Abstract

A Mn-catalyzed N-F bond activation enables a visible-light-promoted generation of amidyl radicals from N-fluorosulfonamides. In the presence of a cheap silane, (MeO)₃SiH as hydrogen-atom donor and F-atom acceptor, intra- and intermolecular hydroaminations of alkenes, two-component carboamination of alkenes, and even three-component carboamination of alkenes can be realized.

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Key Words

pyrrolidines, trimethoxysilane

ID: J54-Y2021