Synthesis of gem-Difluoroalkenes via a Sequence of Hydroboration and 1,2-Elimination of α,β-Unsaturated Carbonyls

Shiyun An, Jinlong Zhang, Gaoxi Jiang*

*Center for Excellence in Molecular Synthesis, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences, Lanzhou 730000, P. R. of China, Email: gxjianglicp.cas.cn

S. An, J. Zhang, G. Jiang, Synlett, 2021, 32, 91-94.

DOI: 10.1055/s-0040-1707311

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Abstract

Hydroboration of α,β-unsaturated carbonyl substrates followed by 1,2-elimination provides gem-difluoroalkenes under mild conditions. gem-Difluoroalkenes can be converted into β-CF₂H- and β-CFH₂-α,β-unsaturated carbonyls.

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Key Words

gem-difluoroalkenes, boration, 1,2-elimination, α,β-unsaturated carbonyls, fluoroalkenes

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ID: J72-Y2021