Photocatalytic Visible-Light-Induced Nitrogen Insertion via Dual C(sp3)-H and C(sp2)-H Bond Functionalization: Access to Privileged Imidazole-based Scaffolds
Srilaxmi M. Patel, Ermiya Prasad P., Manickam Bakthadoss* and Duddu S. Sharada*
*Pondicherry University, Puducherry 605 014; Indian Institute of Technology Hyderabad, Kandi, Sangareddy, Telangana 502 285, India, Email: bhakthadossyahoo.com, sharadachy.iith.ac.in
S. M. Patel, E. Prasad P., M. Bakthadoss, D. S. Sharada, Org. Lett., 2021, 23, 257-261.
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A visible-light-mediated metal-free organic-dye-catalyzed dehydrogenative N-insertion provides highly substituted imidazoles and privileged dihydroisoquinoline-based imidazole derivatives. This sustainable, convenient, metal-free azidation/C-H aminative cyclization approach works without oxidants via a photoinduced iminyl radical as key intermediate for the nitrogen insertion.
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