Palladium-Catalyzed Direct C-H Arylation of 3-Butenoic Acid Derivatives
Shan Yang, Lingling Liu, Zheng Zhou, Zhibin Huang* and Yingsheng Zhao*
*College of Chemistry, Chemical Engineering and Materials Science, Soochow
University, Suzhou 215123, P. R. China, Email: zbhuang
suda.edu.cn,
yszhaosuda.edu.cn
S. Yang, L. Liu, Z. Zhou, Z. Huang, Y. Zhao, Org. Lett., 2021, 23, 296-299.
DOI: 10.1021/acs.orglett.0c03773
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Abstract
A carboxylic-acid-directed oxidative Heck reaction enables a direct synthesis of 4-aryl-3-butenoic acids in good yields.
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proposed mechanism
Key Words
arylation, copper compounds, Heck reaction
ID: J54-Y2021
