Cu-Catalyzed Oxidative Thioesterification of Aroylhydrazides with Disulfides
Shimin Xie, Lebin Su, Min Mo, Wang Zhou, Yongbo Zhou and Jianyu Dong*
*Department of Educational Science, Hunan First Normal University, Changsha 410205, China,
Email: djyustc
hotmail.com
S. Xie, L. Su, M. Mo, W. Zhou, Y. Zhou, J. Dong, J. Org. Chem., 2021, 86, 739-749.
DOI: 10.1021/acs.joc.0c02328
see article for more reactions
Abstract
A copper-catalyzed oxidative coupling of readily available aroylhydrazides with disulfides enables an alternative thioesterification reaction, in which oxidative expulsion of N2 overcomes the activation barrier between the carboxylic acid derivatives and the products. The reaction produces various thioesters in good to excellent yields with good functional group tolerance.
see article for more examples
Key Words
thioesterification, ammonium peroxydisulfate
ID: J42-Y2021
