Counterion-Enhanced Pd/Enamine Catalysis: Direct Asymmetric α-Allylation of Aldehydes with Allylic Alcohols by Chiral Amines and Achiral or Racemic Phosphoric Acids
Ádám Márk Pálvölgyi, Jakob Smith, Michael Schnürch and Katharina Bica-Schröder*
*Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/163, A-1060 Vienna, Austria,
Email: katharina.schroeder
tuwien.ac.at
Á. M. Pálvölgyi, J. Smith, M. Schnürch, K. Bica-Schröder, J. Org. Chem., 2021, 86, 850-860.
DOI: 10.1021/acs.joc.0c02385
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Abstract
A straightforward and efficient Pd/enamine catalytic procedure enables the direct asymmetric α-allylation of branched aldehydes with different allylic alcohols in the presence of a simple chiral amine and an easily prepared achiral or racemic phosphoric acid.
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proposed mechanism
Key Words
allylation of carbonyl compounds
ID: J42-Y2021
