Ni-Catalyzed Isomerization-Hydrocyanation Tandem Reactions: Access to Linear Nitriles from Aliphatic Internal Olefins
Jihui Gao, Jie Ni, Rongrong Yu, Gui-Juan Cheng* and Xianjie Fang*
*The Chinese University of Hong Kong, Shenzhen 518172; Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China, Email: chengguijuancuhk.edu.cn, fangxjsjtu.edu.cn
J. Gao, J. Ni, R. Yu, G.-J. Cheng, X. Fang, Org. Lett., 2021, 23, 486-490.
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A nickel complex catalyzes a highly regioselective isomerization/hydrocyanation of aliphatic internal olefins to provide facile access to a wide variety of aliphatic nitriles in very good yields. Thanks to Lewis acid-free conditions, the protocol tolerates a broad range of functional groups, including secondary amines and unprotected alcohols.
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