Organocatalytic Strategy for the Fixation of CO₂ via Carboxylation of Terminal Alkynes

Jun-Bin Shi, Qingqing Bu, Bin-Yuan Liu*, Bin Dai and Ning Liu*

*School of Chemistry and Chemical Engineering, Shihezi University, North Fourth Road, Shihezi, Xinjiang 832003, P. R. China, Email: byliuhebut.edu.cn, ningliushzu.edu.cn

J.-B. Shi, Q. Bu, B.-Y. Liu, B. Dai, N. Liu, J. Org. Chem., 2021, 86, 1850-1860.

DOI: 10.1021/acs.joc.0c02673

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Abstract

The use of a bifunctional organocatalyst and Cs₂CO₃ enables a direct carboxylation of terminal alkynes with CO₂ at atmospheric pressure under mild temperatures to provide a range of propiolic acid derivatives in high yields with broad substrate scope. This work has demonstrated that this organocatalytic method offers a competitive alternative to metal catalysis.

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proposed mechanism

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Key Words

organocatalysis, carboxylation

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ID: J42-Y2021