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Epimerization-Free C-Term Activation of Peptide Fragments by Ball Milling

Yves Yeboue, Marion Jean, Gilles Subra, Jean Martinez, Frédéric Lamaty* and Thomas-Xavier Métro*

*IBMM, Univ Montpellier, CNRS, ENSCM, Montpellier, France, Email:,

Y. Yeboue, M. Jean, G. Subra, J. Martinez, F. Lamaty, T.-X. Métro, Org. Lett., 2021, 23, 631-635.

DOI: 10.1021/acs.orglett.0c03209

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Mechanochemical coupling of peptide fragments containing highly epimerization-prone and/or highly hindered amino acids at C-term provided peptides in high yields and very low epimerization. Ball milling was clearly identified as the key element to obtain such results.

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method outline

Key Words

amides, mechanochemistry

ID: J54-Y2021