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N-Methylation of Amines with Methanol in the Presence of Carbonate Salt Catalyzed by a Metal-Ligand Bifunctional Ruthenium Catalyst [(p-cymene)Ru(2,2'-bpyO)(H2O)]

Peng Liu, Nguyen Thanh Tung, Xiangchao Xu, Jiazhi Yang* and Feng Li*

*School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, People's Republic of China, Email: jiazhiyangnjust.edu.cn, fenglinjust.edu.cn

P. Liu, N. T. Tung, X. Xu, J. Yang, F. Li, J. Org. Chem., 2021, 86, 2621-2631.

DOI: 10.1021/acs.joc.0c02685


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Abstract

[(p-cymene)Ru(2,2'-bpyO)(H2O)] is a general and efficient catalyst for the N-methylation of amines and sulfonamides with methanol in the presence of a carbonate salt. The reaction tolerates a series of sensitive substituents, such as nitro, ester, cyano, and vinyl groups.

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Key Words

sulfonamides, arylamines, alkylamines


ID: J42-Y2021