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Acyl Fluorides from Carboxylic Acids, Aldehydes, or Alcohols under Oxidative Fluorination

Yumeng Liang, Zhengyu Zhao, Akihito Taya and Norio Shibata*

*Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan, Email:

Y. Liang, Z. Zhao, A. Taya, N. Shibata, Org. Lett., 2021, 23, 847-852.

DOI: 10.1021/acs.orglett.0c04087

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The combination of trichloroisocyanuric acid and cesium fluoride provides acyl fluorides directly from three different functional group precursors: carboxylic acids, aldehydes, or alcohols. It can be applied to the late-stage functionalization of natural products and drug molecules.

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Key Words

acyl fluorides, TCCA

ID: J54-Y2021