Selective Catalytic Synthesis of α-Alkylated Ketones and β-Disubstituted Ketones via Acceptorless Dehydrogenative Cross-Coupling of Alcohols
Dipanjan Bhattacharyya, Bikash Kumar Sarmah, Sekhar Nandi, Hemant Kumar Srivastava* and Animesh Das*
*Institute of Pharmaceutical Education and Research, Guwahati 781101; Indian Institute of Technology, Guwahati 781039, Assam, India, Email: srivastava.hkniperguwahati.ac.in, adasiitg.ac.in
D. Bhattacharyya, B. K. Sarmah, S. Nandi, H. K. Srivastava, A. Das, Org. Lett., 2021, 23, 869-875.
see article for more reactions
A phosphine-free pincer ruthenium(III) catalyzed β-alkylation of secondary alcohols with primary and secondary alcohols provides α-alkylated ketones. This transformation is environmentally benign and atom efficient with H2O and H2 as the only byproducts. The protocol is extended to gram-scale reaction and for functionalization of complex vitamin E and cholesterol derivatives.
see article for more examples