Hypervalent Iodine Reagent-Promoted Hofmann-Type Rearrangement/Carboxylation of Primary Amides
Xia Wang, Peng Yang, Bo Hu, Qian Zhang and Dong Li*
*School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, China, Email: donglimail.hbut.edu.cn
X. Wang, P. Yang, B. Hu, Q. Zhang, D. Li, J. Org. Chem., 2021, 86, 2820-2826.
Hypervalent iodine reagents promote a facile and efficient transformation of primary amides to secondary amides. The hypervalent iodine reagent mediates a Hofmann-type rearrangement to an isocyanate intermediate, which is subsequently trapped by an in situ generated carboxylic acid from the hypervalent iodine reagent to provide the corresponding secondary amides.
see article for more examples