Regio-, Chemo-, and Enantioselective Ni-Catalyzed Hydrocyanation of 1,3-Dienes
Rongrong Yu, Yidan Xing and Xianjie Fang*
*School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China,
Email: fangxj
sjtu.edu.cn
R. Yu, Y. Xing, X. Fang, Org. Lett., 2021, 23, 930-935.
DOI: 10.1021/acs.orglett.0c04133
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Abstract
Multichiral diphosphite ligands enable a regio-, chemo-, and enantioselective nickel-catalyzed hydrocyanation of 1,3-dienes. In addition to aryl-substituted 1,3-dienes, highly challenging aliphatic 1,3-diene substrates can also be converted to the corresponding 1,2-adducts with high enantioselectivities.
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Key Words
ID: J54-Y2021
