Decarboxylative C(sp³)-N Cross-Coupling of Diacyl Peroxides with Nitrogen Nucleophiles

Zi-Liang Tang, Xuan-Hui Ouyang*, Ren-Jie Song and Jin-Heng Li*

*Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang Hangkong University, Nanchang 330063, China, Email: xuanhuiouyang163.com, jhlihnu.edu.cn

Z. -L. Tang, X.-H. Ouyang, R.-J. Song, J.-H. Li, Org. Lett., 2021, 23, 1000-1004.

DOI: 10.1021/acs.orglett.0c04203

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Abstract

A radical-mediated decarboxylative C(sp³)-N cross-coupling of diacyl peroxides with nitrogen nucleophiles, including indazoles, triazoles, indoles, and anilines provides a broad range of alkylated products. The primary and secondary alkyl radicals derived from corresponding diacyl peroxides were generated by copper catalysis or by merging copper catalysis and photoredox catalysis, respectively.

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Key Words

aryl amines, indazoles, N-heterocycles

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ID: J54-Y2021