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Selective Reduction of Nitroarenes to Arylamines by the Cooperative Action of Methylhydrazine and a Tris(N-heterocyclic thioamidate) Cobalt(III) Complex

Dimitris I. Ioannou, Dimitra K. Gioftsidou, Vasiliki E. Tsina, Michael G. Kallitsakis, Antonios G. Hatzidimitriou, Michael A. Terzidis, Panagiotis A. Angaridis* and Ioannis N. Lykakis*

*Department of Chemistry, Aristotle University of Thessaloniki, University Campus, Thessaloniki 54124, Greece, Email: panosangaridischem.auth.gr, lykakischem.auth.gr

D. I. Ioannou, D. K. Gioftsidou, V. E. Tsina, M. G. Kallitsakis, A. G. Hatzidimitriou, M. A. Terzidis, P. A. Angaridis, I. N. Lykakis, J. Org. Chem., 2021, 86, 2895-2906.

DOI: 10.1021/acs.joc.0c02814 (free Supporting Information)


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Abstract

The use of methylhydrazine as a reducing agent in combination with an easily synthesized and robust Co catalyst and a polar protic solvent enables a chemoselectively reduction of nitroarenes to arylamines in excellent yields.


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[Co(κS,N-tfmp2S)3]



Selective Photoinduced Reduction of Nitroarenes to N-Arylhydroxylamines

M. G. Kallitsaki, D. I. Ioannou, M. A. Terzidis, G. E. Kostakis, J. N. Lykakis, Org. Lett., 2020, 22, 4339-4343.


Key Words

methylhydrazine, reduction of nitrocompounds


ID: J42-Y2021