C-C Bond Cleavage Initiated Cascade Reaction of β-Enaminones: One-Pot Synthesis of 5-Hydroxy-1H-pyrrol-2(5H)-ones
Ting Chen, Xiujuan Zheng, Wenhua Wang, Yadong Feng, Yanyun Wang and Jinhai Shen*
*School of Environment and Public Health, Xiamen Key Laboratory of Food and Drug Safety, Xiamen Huaxia University, Xiamen, Fujian 361024, China,
Email: shenjh
hxxy.edu.cn
T. Chen, X. Zhang, W. Wang, Y. Feng, Y. Wang, J. Shen, J. Org. Chem., 2021, 86, 2917-2928.
DOI: 10.1021/acs.joc.0c02832
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Abstract
An unprecedented C(CO)-C(Ar) bond cleavage of β-enaminones under mild and transition-metal-free conditions followed by 1,3-O/C migration and aerobic hydroxylation provides various 5-hydroxy-1H-pyrrol-2(5H)-ones with broad functional group tolerance.
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proposed mechanism
Key Words
ID: J42-Y2021
