Organic Chemistry Portal

Abstracts

Search:

Electrochemical Desulfurative Cyclization Accessing Oxazol-2-amine Derivatives via Intermolecular C-N/C-O Bond Formation

Jinhui Hu*, Huanliang Hong, Yongwei Qin, Yunfei Hu, Suyun Pu, Gen Liang and Yubing Huang

*School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529090, P. R. China, Email: wyuchemhjh126.com

J. Hu, H. Hong, Y. Qin, Y. Hu, S. Pu, G. Liang, Y. Huang, Org. Lett., 2021, 23, 1016-1020.

DOI: 10.1021/acs.orglett.0c04218


Abstract

A practical electrochemical desulfurative cyclization of isothiocyanates and α-amino ketones provides diverse oxazol-2-amine derivatives in one step in good yields. The reaction is performed under metal- and external-oxidant-free electrolytic conditions to achieve the formation of intermolecular C-O and C-N bonds.


see article for more examples

proposed mechanism



Key Words

oxazoles, electrochemistry


ID: J54-Y2021