Electrochemical Desulfurative Cyclization Accessing Oxazol-2-amine Derivatives via Intermolecular C-N/C-O Bond Formation
Jinhui Hu*, Huanliang Hong, Yongwei Qin, Yunfei Hu, Suyun Pu, Gen Liang and Yubing Huang
*School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529090, P. R. China, Email: wyuchemhjh126.com
J. Hu, H. Hong, Y. Qin, Y. Hu, S. Pu, G. Liang, Y. Huang, Org. Lett., 2021, 23, 1016-1020.
DOI: 10.1021/acs.orglett.0c04218
Abstract
A practical electrochemical desulfurative cyclization of isothiocyanates and α-amino ketones provides diverse oxazol-2-amine derivatives in one step in good yields. The reaction is performed under metal- and external-oxidant-free electrolytic conditions to achieve the formation of intermolecular C-O and C-N bonds.
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proposed mechanism
Key Words
oxazoles, electrochemistry
ID: J54-Y2021