Conversion of Aryl Aldehydes to Benzyl Iodides and Diarylmethanes by H3PO3/I2
Fang Lv, Jing Xiao*, Junchun Xiang, Fengzhe Guo, Zi-Long Tang and Li-Biao Han*
*Hunan University of Science and Technology, Xiangtan 411201, China; AIST, Tsukuba, Ibaraki 305-8565, Japan,
Email: XiaoJing
hnust.edu.cn, libiao-hanaist.go.jp
F. Lv, J. Xiao, J. Xiang, F. Guo, Z.-L. Tang, L.-B. Han, J. Org. Chem., 2021, 86, 3081-3088.
DOI: 10.1021/acs.joc.0c02850
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Abstract
The use of H3PO3/I2 enables a reductive iodination of various aromatic aldehydes to produce benzyl iodides. The benzyl iodides can be converted into diarylmethanes or cyclic compounds in good yields via in situ Friedel-Crafts type reactions.
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proposed mechanism
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Key Words
benzyl iodides, Friedel-Crafts alkylation, hypophosphorous acid
ID: J42-Y2021
