Aerobic Oxidative Dehydrogenation of Ketones to 1,4-Enediones
Bao-Yin Zhao, Xing-Long Zhang, Rui-Li Guo, Meng-Yue Wang, Ya-Ru Gao and Yong-Qiang Wang*
*Department of Chemistry & Materials Science, Northwest University, Xi'an 710069, P.R. China, Email: wangyqnwu.edu.cn
B.-Y. Zhao, X.-L. Zhang, R.-L. Guo, M.-Y. Wang, Y.-R. Gao, Y.-Q. Wang, Org. Lett., 2021, 23, 1216-1221.
DOI: 10.1021/acs.orglett.0c04174
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Abstract
A palladium-catalyzed oxidative dehydrogenation enables an efficient synthesis of 1,4-enediones from saturated ketones in the presence of molecular oxygen as the sole oxidant. This atom- and step-economic process offers broad substrate scope, good functional group tolerance, and complete E-stereoselectivity.
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Key Words
enones (C=C formation, C=O oxidation), oxygen
ID: J54-Y2021