Using Chlorotrifluoroethane for Trifluoroethylation of (Hetero)aryl Bromides and Chlorides via Nickel Catalysis

Xuefei Li, Xing Gao, Chun-Yang He and Xingang Zhang*

*Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China, Email: xgzhangmail.sioc.ac.cn

X. Li, X. Gao, C.-Y. He, X. Zhang, Org. Lett., 2021, 23, 1400-1405.

DOI: 10.1021/acs.orglett.1c00058

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Abstract

A nickel-catalyzed reductive cross-coupling between industrial chemical CF₃CH₂Cl and (hetero)aryl bromides and chlorides is synthetically simple, avoids the preparation of arylmetals, and exhibits high functional group tolerance.

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Key Words

benzylic trifluoromethanes, alkylation, zinc

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ID: J54-Y2021