Organic Chemistry Portal



Ruthenium-Catalyzed Oxidative Cross-Coupling Reaction of Activated Olefins with Vinyl Boronates for the Synthesis of (E,E)-1,3-Dienes

Dattatraya H. Dethe*, Nagabhushana C. Beeralingappa and Amar Uike

*Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India, Email:

D. H. Dethe, N. C. Beeralingappa, A. Uike, J. Org. Chem., 2021, 86, 3444-3455.

DOI: 10.1021/acs.joc.0c02823

see article for more reactions


An oxidative cross-coupling reaction between activated olefins and vinyl boronate provides synthetically useful (E,E)-1,3-dienes. Exclusive stereoselectivity (only E,E-isomer) was achieved using base-free, ligand-free, and mild catalytic conditions with [RuCl2(p-cymene)]2 as catalyst.

see article for more examples

Key Words

1,3-Dienes, Copper(II)

ID: J42-Y2021