Synthesis of N-Alkyl Anilines from Arenes via Iron-Promoted Aromatic C-H Amination
Eric Falk, Valentina C. M. Gasser and Bill Morandi*
*ETH Zürich, Vladimir-Prelog-Weg 3, HCI, 8093 Zürich, Switzerland,
Email: bill.morandi
org.chem.ethz.ch
E. Falk, V. C. M. Gasser, B. Morandi, Org. Lett., 2021, 23, 1422-1426.
DOI: 10.1021/acs.orglett.1c00099
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Abstract
A mild Fe-mediated intermolecular C-H amination of arenes with a highly electrophilic aminating reagent provides unprotected N-methylanilines. An intramolecular variant for the synthesis of tetrahydroquinolines has also been developed. The reactions display a broad functional group tolerance.
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Key Words
ID: J54-Y2021
