Organic Chemistry Portal



Synthesis of N-Alkyl Anilines from Arenes via Iron-Promoted Aromatic C-H Amination

Eric Falk, Valentina C. M. Gasser and Bill Morandi*

*ETH Zürich, Vladimir-Prelog-Weg 3, HCI, 8093 Zürich, Switzerland, Email:

E. Falk, V. C. M. Gasser, B. Morandi, Org. Lett., 2021, 23, 1422-1426.

DOI: 10.1021/acs.orglett.1c00099

see article for more reactions


A mild Fe-mediated intermolecular C-H amination of arenes with a highly electrophilic aminating reagent provides unprotected N-methylanilines. An intramolecular variant for the synthesis of tetrahydroquinolines has also been developed. The reactions display a broad functional group tolerance.

see article for more examples

Key Words


ID: J54-Y2021