Palladium-Catalyzed Synthesis of Polysubstituted Pyrazoles by Ring-Opening Reactions of 2H-Azirines with Hydrazones

Jiaan Shao*, Ke Shu, Shuangrong Liu, Huajian Zhu, Jiankang Zhang, Chong Zhang, Ling-Hui Zeng, Wenteng Chen*

*School of Medicine and College of Pharmaceutical Sciences, Zhejiang University City College, Hangzhou, 310015, P. R. of China, Email: shaojazucc.edu.cn, wentengchenzucc.edu.cn

J. Shao, K. Shu, S. Liu, H. Zhu, J. Zhang, C. Zhang, L.-H. Zeng, L. Zeng, W. Chen, J. An, Synlett, 2021, 32, 316-320.

DOI: 10.1055/s-0040-1707262

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Abstract

A palladium-catalyzed ring-opening reaction of 2H-azirines with hydrazones provides polysubstituted pyrazoles with a wide substrate scope.

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Key Words

palladium catalysis, ring opening, azirines, hydrazones, pyrazoles, potassium peroxydisulfate

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ID: J72-Y2021