Synthesis of Substituted Anilines from Cyclohexanones Using Pd/C-Ethylene System and Its Application to Indole Synthesis
Katsumi Maeda, Ryosuke Matsubara and Masahiko Hayashi*
*Department of Chemistry, Graduate School of Science, Kobe University, Kobe 657-8501, Japan, Email: mhayashikobe-u.ac.jp
K. Maeda, R. Matsubara, M. Hayashi, Org. Lett., 2021, 23, 1530-1534.
see article for more reactions
The use of a Pd/C-ethylene system enables a synthesis of anilines and indoles from cyclohexanones in the presence of NH4OAc. Hydrogen transfer between cyclohexanone and ethylene generates the desired products. The reaction tolerates a variety of substitutions on the starting cyclohexanones.
see article for more examples