Electrochemically Enabled, Nickel-Catalyzed Dehydroxylative Cross-Coupling of Alcohols with Aryl Halides

Zijian Li, Wenxuan Sun, Xianxu Wang, Luyang Li, Yong Zhang and Chao Li*

*National Institute of Biological Sciences, Beijing, 102206, China, Email: lichaonibs.ac.cn

Z. Li, W. Sun, X. Wang, L. Li, Y. Zhang, C. Li, J. Am. Chem. Soc., 2021, 143, 3586-3543.

DOI: 10.1021/jacs.0c13093

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Abstract

The combination of anodic preparation of alkoxy triphenylphosphonium ion and nickel-catalyzed cathodic reductive cross-coupling enables an efficient method to construct C(sp²)-C(sp³) bonds, in which free alcohols and aryl bromides can be directly used as coupling partners.

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proposed mechanism

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Key Words

alkylation, benzylation, electrochemistry

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ID: J48-Y2021