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Iron-Catalyzed α,β-Dehydrogenation of Carbonyl Compounds

Xiao-Wei Zhang, Guo-Qing Jiang, Shu-Hui Lei, Xiang-Huan Shan, Jian-Ping Qu* and Yan-Biao Kang*

*Nanjing Tech University, Nanjing 211816; University of Science and Technology of China, Hefei, Anhui 230026, China, Email:,

X.-W. Zhang, G.-Q. Jiang, S.-H. Lei, X.-H. Shan, J.-P. Qu, Y.-B. Kang, Org. Lett., 2021, 23, 1611-1615.

DOI: 10.1021/acs.orglett.1c00043

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An iron-catalyzed α,β-dehydrogenation of carbonyl compounds converts a broad range of aldehydes, ketones, lactones, lactams, amines, and alcohols to their α,β-unsaturated counterparts in a simple one-step reaction with high yields.

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proposed mechanism

Key Words

enals, TEMPO

ID: J54-Y2021