Rhodium-Catalyzed Asymmetric Transfer Hydrogenation/Dynamic Kinetic Resolution of 3-Benzylidene-Chromanones

Ricardo Molina Betancourt, Phannarath Phansavath* and Virginie Ratovelomanana-Vidal*

*PSL University, Chimie ParisTech, CNRS, Institute of Chemistry for Life and Health Sciences, CSB2D Team, 75005 Paris, France, Email: phannarath.phansavathchimieparistech.psl.eu, virginie.vidalchimieparistech.psl.eu

R. M. Betancourt, P. Phansavath, V. Ratovelomanana-Vidal, Org. Lett., 2021, 23, 1621-1625.

DOI: 10.1021/acs.orglett.1c00047

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Abstract

Rh-catalyzed asymmetric transfer hydrogenation enables a straightforward access to enantiomerically enriched cis-3-benzyl-chromanols from (E)-3-benzylidene-chromanones in the presence of HCO₂H/DABCO as the hydrogen source.

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Key Words

chromans, formic acid

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ID: J54-Y2021