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Electrochemical Oxidation Enables Regioselective and Scalable α-C(sp3)-H Acyloxylation of Sulfides

Huamin Wang, Meng He, Yongli Li, Heng Zhang, Dali Yang, Masanari Nagasaka, Zongchao Lv, Zhipeng Guan, Yangmin Cao, Fengping Gong, Zhilin Zhou, Jingyun Zhu, Supravat Samanta, Abhishek Dutta Chowdhury and Aiwen Lei*

*College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, People’s Republic of China, Email:

H. Wang, M. He, Y. Li, H. Zhang, D. Yang, M. Nagasaka, Z. Lv, Z. Guan, Y. Cao, F. Gong, Z. Zhou, J. Zhu, S. Samanta, A. D. Chowdhury, A. Lei, J. Am. Chem. Soc., 2021, 143, 3628-3637.

DOI: 10.1021/jacs.1c00288

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A highly selective, environmentally friendly, and scalable electrochemical α-C(sp3)-H acyloxylation of sulfides enables the construction of α-acyloxy sulfides. The method offers exceptionally broad substrate scope, high regioselectivity, gram-scale synthesis, and construction of complex molecules.

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Key Words

electrochemistry, O,S-Acetals

ID: J48-Y2021