Nickel-Catalyzed Reversible Functional Group Metathesis between Aryl Nitriles and Aryl Thioethers
Tristan Delcaillau, Philip Boehm and Bill Morandi*
*ETH Zürich, Vladimir-Prelog-Weg 3, HCI, 8093 Zürich, Switzerland,
Email: bill.morandi
org.chem.ethz.ch
T. Delcaillau, P. Boehm, B. Morandi, J. Am. Chem. Soc., 2021, 143, 3628-3637.
DOI: 10.1021/jacs.1c00529
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Abstract
The combination of nickel/dcype is essential to achieve a fully reversible functional group metathesis between aryl nitriles and aryl thioethers in very good yields. This cyanide- and thiol-free reaction shows high functional group tolerance and great efficiency for the late-stage derivatization of commercial molecules.
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Nickel-Catalyzed Cyanation of Aryl Thioethers
T. Delcaillau, A. Woenckhaus-Alvare, B. Morandi, Org. Lett., 2021, 23, 7018-7022.
Key Words
ID: J48-Y2021
