Deoxyfluorination of Carboxylic Acids with CpFluor: Access to Acyl Fluorides and Amides
Xiu Wang, Fei Wang, Fengfeng Huang, Chuanfa Ni and Jinbo Hu*
*Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China,
Email: jinbohu
sioc.ac.cn
X. Wang, F. Wang, F. Huang, C. Ni, J. Hu, Org. Lett., 2021, 23, 1764-1768.
DOI: 10.1021/acs.orglett.1c00190
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Abstract
3,3-Difluoro-1,2-diphenylcyclopropene (CpFluor), a bench-stable fluorination reagent, can be used for an efficient deoxyfluorination of (hetero)aryl, alkyl, alkenyl, and alkynyl carboxylic acids to the corresponding acyl fluorides under neutral conditions. A synthesis of acyl fluorides with in-situ formed CpFluor, as well as a one-pot amidation reaction are also described.
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Key Words
ID: J54-Y2021
