Dimethylamination of Primary Alcohols Using a Homogeneous Iridium Catalyst: A Synthetic Method for N,N-Dimethylamine Derivatives

Jaeyoung Jeong and Ken-ichi Fujita*

*Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan, Email: fujita.kenichi.6akyoto-u.ac.jp

J. Jeong, K.-i. Fujita, J. Org. Chem., 2021, 86, 4053-4060.

DOI: 10.1021/acs.joc.0c02896

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Abstract

An iridium catalyst bearing an N-heterocyclic carbene mediates an N,N-dimethylamination of primary alcohols with aqueous dimethylamine in the absence of additional organic solvents via an atom-efficient and environmentally benign borrowing hydrogen process.

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Efficient and Versatile Catalytic Systems for the N-Methylation of Primary Amines with Methanol Catalyzed by N-Heterocyclic Carbene Complexes of Iridium

G. Toyooka, A. Tuji, K.-i. Fujita, Synthesis, 2018, 50, 4617-4626.

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Key Words

amines

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ID: J42-Y2021