Dimethylamination of Primary Alcohols Using a Homogeneous Iridium Catalyst: A Synthetic Method for N,N-Dimethylamine Derivatives
Jaeyoung Jeong and Ken-ichi Fujita*
*Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan, Email: fujita.kenichi.6akyoto-u.ac.jp
J. Jeong, K.-i. Fujita, J. Org. Chem., 2021, 86, 4053-4060.
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An iridium catalyst bearing an N-heterocyclic carbene mediates an N,N-dimethylamination of primary alcohols with aqueous dimethylamine in the absence of additional organic solvents via an atom-efficient and environmentally benign borrowing hydrogen process.
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G. Toyooka, A. Tuji, K.-i. Fujita, Synthesis, 2018, 50, 4617-4626.