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Modular Domino Process toward Highly Functionalized Pyrroles via Pd-Catalyzed [4 + 1] Annulation under Mild Conditions

Linhong Zuo, Yulian Yang and Wusheng Guo*

*Frontier Institute of Science and Technology (FIST), Xi'an Jiaotong University, Xi'an, Shaanxi 710045, China, Email: wusheng.guomail.xjtu.edu.cn

L. Zuo, Y. Yang, W. Guo, Org. Lett., 2021, 23, 2013-2018.

DOI: 10.1021/acs.orglett.1c00148


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Abstract

A Pd-catalyzed decarboxylative reaction of readily available cyclic carbonates and amines provides highly functionalized pyrroles and only generates CO2 and H2O as byproducts. The reaction works at room temperature and open to air, and is suitable for the derivatization of bioactive compounds.

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Key Words

pyrroles


ID: J54-Y2021