Organic Chemistry Portal



Coupling Photocatalysis and Substitution Chemistry to Expand and Normalize Redox-Active Halides

Manjula D. Rathnayake and Jimmie D. Weaver III*

*Department of Chemistry, Oklahoma State University, 107 Physical Sciences, Stillwater, Oklahoma 74078, United States, Email:

M. D. Rathnayake, J. D. Weaver III, Org. Lett., 2021, 23, 2036-2041.

DOI: 10.1021/acs.orglett.1c00173

see article for more reactions


When used with photocatalysis, bench-stable, commercially available collidinium salts are excellent radical precursors with a broad scope, that can substitute alkyl halides. Furthermore, all of the reaction components are water-soluble, which facilitates product isolation.

see article for more examples

Key Words

benzylation, nitriles, esters, photochemistry

ID: J54-Y2021