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Trimethyl Borate-Catalyzed, Solvent-Free Reductive Amination

P. Veeraraghavan Ramachandran*, Shivani Choudhary and Aman Singh

*Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907-2084, United States, Email:

P. V. Ramachandran, S. Choudhary, A. Singh, J. Org. Chem., 2021, 86, 4274-4280.

DOI: 10.1021/acs.joc.0c02143


Trimethyl borate promotes a solvent-free reductive amination of aldehydes and ketones with aliphatic and aromatic amines in very good yields in the presence of ammonia borane as reductant.

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Key Words

reductive amination, ammonia borane

ID: J42-Y2021