Formal Enone α-Arylation via I(III)-Mediated Aryl Migration/Elimination
Bruna S. Martins, Daniel Kaiser, Adriano Bauer, Irmgard Tiefenbrunner and Nuno Maulide*
*University of Vienna, Institute of Organic Chemistry, Währinger Strasse 38, 1090 Vienna, Austria,
Email: nuno.maulide
univie.ac.at
B. S. Martins, D. Kaiser, A. Bauer, I. Tiefenbrunner, N. Maulide, Org. Lett., 2021, 23, 2094-2098.
DOI: 10.1021/acs.orglett.1c00251
Abstract
An I(III)-mediated skeletal reorganization of silyl enol ethers enables a formal enone α-arylation. This metal-free transformation offeres mild conditions, good yields, and high stereoselectivities for β-substituted enones.
see article for more examples
proposed reaction pathway
Key Words
ID: J54-Y2021
