Enantioselective Radical Carbocyanation of 1,3-Dienes via Photocatalytic Generation of Allylcopper Complexes
Fu-Dong Lu, Liang-Qiu Lu, Gui-Feng He, Jun-Chuan Bai and Wen-Jing Xiao*
*College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, China,
Email: wxiao
mail.ccnu.edu.cn
F.-D. Lu, L. Q. Lu, G.-F. He, J.-C. Bai, W.-J. Xiao, J. Am. Chem. Soc., 2021, 143, 4168-4173.
DOI: 10.1021/jacs.1c01260
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Abstract
By using synergetic photoredox/copper catalysis, a visible-light-induced, enantioselective carbocyanation of 1,3-dienes with carboxylic acid derivatives and trimethylsilyl cyanide is achieved under mild and neutral conditions. A diverse range of chiral allyl cyanides is produced in generally good efficiency and with high enantioselectivity from bench-stable and user-safe chemicals.
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proposed mechanism
Key Words
cyanation, alkylation, multicomponent reactions, photochemistry
ID: J48-Y2021
