Mizoroki-Heck Reaction of Unstrained Aryl Ketones via Ligand-Promoted C-C Bond Olefination
Mei-Ling Wang, Hui Xu, Han-Yuan Li, Biao Ma, Zhen-Yu Wang, Xing Wang and Hui-Xiong Dai*
*Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, Shanghai 201203, China,
Email: hxdai
simm.ac.cn
M.-L. Wang, H. Xu, H.-Y. Li, B. Ma, Z.-Y. Wang, X. Wang, H.-X. Dai, Org. Lett., 2021, 23, 2147-2152.
DOI: 10.1021/acs.orglett.1c00296
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Abstract
A palladium-catalyzed ligand-promoted C-C bond cleavage enables a Mizoroki-Heck reaction of unstrained aryl ketones with acrylates/styrenes to afford alkene products in very good yields.
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Key Words
ID: J54-Y2021
