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Mizoroki-Heck Reaction of Unstrained Aryl Ketones via Ligand-Promoted C-C Bond Olefination

Mei-Ling Wang, Hui Xu, Han-Yuan Li, Biao Ma, Zhen-Yu Wang, Xing Wang and Hui-Xiong Dai*

*Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, Shanghai 201203, China, Email:

M.-L. Wang, H. Xu, H.-Y. Li, B. Ma, Z.-Y. Wang, X. Wang, H.-X. Dai, Org. Lett., 2021, 23, 2147-2152.

DOI: 10.1021/acs.orglett.1c00296

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A palladium-catalyzed ligand-promoted C-C bond cleavage enables a Mizoroki-Heck reaction of unstrained aryl ketones with acrylates/styrenes to afford alkene products in very good yields.

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Key Words

Heck reaction, alkenylation

ID: J54-Y2021