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Copper-Catalyzed Asymmetric Borylacylation of Styrene and Indene Derivatives

Zhen Yang, Peiyuan Li, Hongjian Lu* and Guigen Li*

*Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China, Email: hongjianlunju.edu.cn, guigenlinju.edu.cn

Z. Yang, P. Li, H. Lu, G. Li, J. Org. Chem., 2021, 86, 4616-4624.

DOI: 10.1021/acs.joc.1c00031 (free Supporting Information)


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Abstract

An enantioselective copper-catalyzed borylacylation of aryl olefins with acyl chlorides and bis-(pinacolato)diboron proceeds with a 2 mol % catalyst loading and is generally completed within 30 min at room temperature. The resulting chiral β-borylated ketones are versatile intermediates in organic synthesis.

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transformations of the products



Key Words

acylation, borylation, multicomponent reactions


ID: J42-Y2021