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Ni-Catalyzed Cross-Electrophile Coupling of Aryl Triflates with Thiocarbonates via C-O/C-O Bond Cleavage

Zhaodong Zhu, Yuxin Gong, Weiqi Tong, Weichao Xue* and Hegui Gong*

*Center for Supramolecular Chemistry and Catalysis and Department of Chemistry, Shanghai University, Shanghai 200444, China, Email:,

Z. Zhu, Y. Gong, W. Tong, W. Xue, H. Gong, Org. Lett., 2021, 23, 2158-2163.

DOI: 10.1021/acs.orglett.1c00313

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A nickel-catalyzed reductive coupling of aryl triflates with O-tBu S-alkyl thiocarbonates provides thioesters in good yields via a chemoselective cleavage of the C-O bond of the thiocarbonate. This work broadens the scope of nickel-catalyzed reductive cross-electrophile coupling reactions.

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Key Words

Carboxylation, Thioesters, Zinc

ID: J54-Y2021