Synthesis of Unnatural α-Amino Acids via Photoinduced Decatungstate-Catalyzed Giese Reactions of Aldehydes
Xinmou Wang, Yuming Chen, Hongjian Song, Yuxiu Liu and Qingmin Wang*
*Research Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, People’s Republic of China, Email: wangqmnankai.edu.cn
X. Wang, Y. Chen, H. Song, Y. Liu, Q. Wang, Org. Lett., 2021, 23, 2199-2204.
DOI: 10.1021/acs.orglett.1c00345 (free Supporting Information)
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Photoinduced decatungstate-catalyzed Giese reactions of readily available aldehydes as radical precursors with dehydroalanine provide γ-carbonyl α-amino acids. This mild, robust method is compatible with a wide array of functional groups and has a broad substrate scope.
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