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Copper-Catalyzed Ring-Opening 1,3-Aminotrifluoromethylation of Arylcyclopropanes

Huan Zhang, Haiwen Xiao, Feng Jiang, Yewen Fang*, Lin Zhu* and Chaozhong Li*

*Ningbo University of Technology, No. 201 Fenghua Road, Ningbo 315211; SIOC, 345 Lingling Road, Shanghai 200032, China, Email:,,

H. Zhang, H. Xiao, F. Jiang, Y. Fang, L. Zhu, C. Li, Org. Lett., 2021, 23, 2268-2272.

DOI: 10.1021/acs.orglett.1c00390

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The copper-catalyzed ring-opening of arylcyclopropanes in the presence of N-fluorobis(arenesulfonyl)imides and (2,2′-bipyridine)Zn(CF3)2 affords γ-trifluoromethylated amines in good yields at room temperature.

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proposed mechanism

Key Words

trifluoromethylation, amination, NFSI

ID: J54-Y2021