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Transition-Metal-Free Synthesis of N-Arylphenothiazines through an N- and S-Arylation Sequence

Tsubasa Matsuzawa, Takamitsu Hosoya and Suguru Yoshida*

*Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan, Email:

T. Matsuzawa, T. Hosoya, S. Yoshida, Org. Lett., 2021, 23, 2347-2352.

DOI: 10.1021/acs.orglett.1c00515

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An N- and S-arylation sequence of o-sulfanylanilines enables an efficient synthesis of various N-arylphenothiazines under transition-metal-free conditions.

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proposed mechanism

Key Words

benzo-fused S-heterocycles, benzo-fused N-heterocycles

ID: J54-Y2021